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Umbrella Review Services

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Umbrella Review and Overview of Reviews for Researchers and Evidence Teams

Pubrica’s subject matter experts and information specialists conduct umbrella reviews, which synthesise existing systematic reviews rather than primary studies, for guideline groups, HTA and policy teams, societies, researchers and medical affairs teams. An umbrella review is the appropriate method when a field already has several systematic reviews and it is unclear whether they agree. You receive a registered protocol, a recorded search, AMSTAR 2 and ROBIS appraisals of every included review, a primary-study overlap matrix with corrected covered area, and a manuscript reported under PRISMA 2020.

  • Overlap measured, not assumed — the primary-study matrix built and corrected covered area reported, showing how much of the apparent evidence comes from the same trials counted more than once
  • Every included review appraised with AMSTAR 2 and ROBIS, because one rates the review’s methodological quality and the other the risk of bias in how it was conducted
  • Disagreement explained rather than averaged — we identify why reviews reached different conclusions instead of averaging their results
  • JBI methodology, reported under PRISMA 2020, with the overlap matrix and appraisal table delivered as working files
  • Clear advice when another method is needed — where the existing reviews are too few or too weak, we advise you before quoting
What Our Umbrella Review Service Includes And what it excludes

Overlap quantified as corrected covered areaIncluded

AMSTAR 2 and ROBIS on every included reviewIncluded

Overlap matrix and appraisal table deliveredIncluded

Disagreement between reviews explainedIncluded

Re-analysis of the primary trialsRequires a systematic review

Reviews → appraised → overlap measured → synthesised → manuscript

Included in every umbrella review
  • Corrected covered area reported
  • AMSTAR 2 and ROBIS applied
  • JBI methodology
  • PRISMA 2020 reporting
  • Overlap matrix delivered
Quoted per reviewBased on the number of reviews included
AMSTAR 2 & ROBISBoth, on every included review
JBI methodologyConduct guidance as well as reporting
ISO 9001:2015Quality management certified · cert. H3CR9TCU20251212INDQM10N

Service Scope

Four Umbrella Review Service Areas, Available Individually

Pubrica provides each stage of an umbrella review as a separate service, so you can outsource the complete review or only the stage you need, such as the overlap analysis and appraisal.

Feasibility AssessmentAn umbrella review requires several existing systematic reviews of adequate quality. Where only two exist, or where all are rated critically low on AMSTAR 2, a new systematic review is the appropriate method, and we advise you of this before quoting.
Overlap measured, not assumedThe same primary studies often appear in several included reviews, so counting reviews double-counts evidence. We build the primary-study matrix and report corrected covered area, the standard measure of how much of the apparent evidence comes from the same trials.
Reviews appraised with AMSTAR 2 and ROBISWe use both instruments because they answer different questions: AMSTAR 2 rates the methodological quality of each review, and ROBIS assesses the risk of bias in how it was conducted. A synthesis of unappraised reviews inherits the flaws of every review it includes.
Disagreement explained rather than averagedWhere included reviews reach different conclusions, we explain why, for example different inclusion criteria, date ranges or pooling decisions. Averaging across reviews that disagree produces a result that cannot inform a decision.

Who we serve

Researchers and Organisations We Support with Umbrella Reviews

We support guideline developers, societies, HTA and policy teams, researchers and medical affairs teams who need a field-level view of existing systematic reviews.

Guideline development groupsSupport where a field has several reviews and no clear answer, and the panel needs to know which reviews to rely on and why they differ.
Clinical and specialty societiesThe state of the evidence across an entire condition rather than one intervention.
HTA and policy teamsA synthesis at the level at which decisions are made, with the overlap between reviews measured.
Researchers planning a new reviewAn assessment of whether a new systematic review is justified, or whether existing reviews already cover the question.
Doctoral scholars and supervisorsA first publishable output that maps a whole field, supported by a documented appraisal.
Medical affairs and publications teamsA field-level evidence summary for a congress or journal, supported by formal appraisal.

Deliverables

What Every Umbrella Review Includes

Every umbrella review assesses the included reviews themselves, rather than listing their conclusions side by side.

Overlap measured, not assumed The same trials often appear in several included reviews, so counting reviews double-counts evidence. We build the primary-study matrix and report corrected covered area, the standard measure of how much of the apparent evidence comes from the same studies counted more than once.

From the overlap matrixEleven systematic reviews were included, covering 214 primary studies.Eleven reviews were included, covering 214 study records but only 63 distinct primary trials. Corrected covered area 18%, which is high overlap — four of the eleven reviews share more than three quarters of their included trials.

Reviews appraised with AMSTAR 2 and ROBIS We apply both instruments because they answer different questions: AMSTAR 2 rates the methodological quality of each included review and identifies critical weaknesses, while ROBIS assesses the risk of bias in the review process. A synthesis of unappraised reviews inherits the flaws of every review it includes.

From the appraisalEleven reviews were included and synthesised.Of eleven included reviews, three were rated critically low on AMSTAR 2 — no protocol, no list of excluded studies, and no assessment of risk of bias in the primary trials. Their conclusions are reported and are not pooled with the rest.

Disagreement explained rather than averaged Where included reviews reach different conclusions, the useful output is why — such as different inclusion dates, different comparators, or one review including an unpublished trial that another excluded. Averaging across reviews that disagree produces a result that cannot inform a decision.

From the synthesisFindings were mixed across the included reviews.Two reviews found benefit and two did not. The difference is entirely the 2023 multicentre trial: the two null reviews had search dates before it published. It is not a genuine disagreement in the evidence.

Clear advice when another method is needed An umbrella review requires several existing systematic reviews of adequate quality. Where only two exist, or where all are rated critically low on AMSTAR 2, a new systematic review of the primary studies is the appropriate method, and we advise you of this before quoting.

From the scoping callThree reviews exist, so an umbrella review is possible.Three reviews exist. Two are critically low, and the third covers a narrower population than your question. An umbrella review here would inherit those problems. A systematic review of the primary studies costs more, and it answers the question you are asking.

These samples are illustrative and anonymised. Hover over a sample to replay it.

Methodology

How Our Umbrella Review Process Works

We complete the appraisal and the overlap matrix before the synthesis, because both affect which conclusions the synthesis can support.

Step one

Question, protocol and search for reviews

We frame the question, register the protocol and search for systematic reviews rather than primary studies, which requires different filters and databases.

Step two

Appraise every included review

Two reviewers apply AMSTAR 2 and ROBIS to each review independently and name the critical weaknesses rather than reducing them to a total score.

Step three

Build the overlap matrix

We map every primary study in every included review and calculate corrected covered area, so the synthesis reflects the amount of independent evidence available.

Step four

Synthesise and report

We synthesise the findings, explain any disagreement, report under PRISMA 2020 and deliver the overlap matrix and appraisal table as working files with the manuscript.

Responsible Use of AI

Responsible Use of AI in Umbrella Reviews

An umbrella review is already one step removed from the primary studies, so we do not add unaudited automation to the reading of the included reviews.

How we use AI toolsWe use AI tools to find candidate reviews, to extract structured fields so that the overlap matrix is built consistently, and to flag where two reviews report the same trial differently.
Where we do not use AI toolsWe do not use AI tools for AMSTAR 2 or ROBIS appraisal, which require expert judgement, for interpreting disagreement between reviews, or for the overlap matrix itself, which a second person checks because a double-counted trial can change the result.
What your AI declaration includesYour declaration states the tool used, the stage at which it was used and the human oversight applied. Journals, funders and the ICMJE January 2026 update expect this information, and an undeclared tool identified later is treated as a research integrity matter.

Why We Do Not Publish an AI Accuracy Figure

Accuracy figures for AI tools are usually reported by the companies that sell them.

For the same reason, Pubrica does not quote an accuracy figure of its own, as it would carry the same conflict of interest. Instead, we tell you which tool was used on your project, at which stage, and what our reviewers changed after it.

Our experts

Your Umbrella Review Team

Your project is handled by a named team of subject specialists who stay with it from scoping to delivery. Your project coordinator introduces each team member before work begins.

Dr. AntonyInformation specialist

Designs and runs the literature search, writing the strategy line by line for each database and delivering it dated and fully reproducible.

Responsible forSearch and retrieval
Works toPRISMA-S, PRESS
Second-checked byA second information specialist
Subject expertA subject matter expert matched to your research topic

Defines the question and scope and checks that every conclusion is supported by the evidence. Matched to your topic, the subject expert advises you directly when the evidence does not support an intended conclusion.

Responsible forQuestion, scope, interpretation
Works toICMJE, COPE, PRISMA
FieldMatched to your topic
Dr. DivyaPhD in Life Science · second reviewer

Reviews the work independently of the first reviewer and reconciles the two, which catches transcription errors. Every disagreement is logged and adjudicated.

Responsible forIndependent second read
Works toRoB 2, ROBINS-I, QUADAS-3, JBI
Adjudicated byA third reviewer
Mr. JohnM.Sc. in Statistics · statistician

Leads the statistical analysis, confirms before analysis begins whether the data can answer the question, and delivers the code so the analysis can be reproduced independently.

Responsible forAnalysis and certainty
Works toGRADE, SWiM, ICH E9
ToolsR, Stata, SAS, RevMan

Packages

Umbrella Review Service Packages

The cost of an umbrella review depends on the number of reviews included and the degree of overlap between them, rather than on record volume as in a systematic review.

Appraisal

Overlap and appraisal only

Teams writing the synthesis themselves

Quoted per projectBased on the number of reviews included

Delivery By scope

  • ✓Search for systematic reviews, recorded per database
  • ✓AMSTAR 2 and ROBIS on every included review
  • ✓Primary-study overlap matrix built
  • ✓Corrected covered area calculated and reported
  • ✓Working files handed over

Add later: the full synthesis and manuscript.

Deliverables Request a quote
Complete

Full umbrella review

Authors and evidence teams publishing the overview

Quoted per projectBased on the number of reviews included

Delivery By scope

  • ✓Everything in Appraisal
  • ✓Protocol registered before the search runs
  • ✓Synthesis with disagreement explained rather than averaged
  • ✓Full manuscript reported under PRISMA 2020
  • ✓Journal formatting and response to reviewer comments

Add later: a systematic review of the primary studies where the reviews will not carry the question.

Deliverables Request a quote

Both packages are quoted individually, because two umbrella reviews with the same number of included reviews can differ in cost by a factor of three once the overlap matrix is built. The scoping search is free, and the quotation is confirmed in writing before work begins.

Benefits

Benefits of a Pubrica Umbrella Review

The main benefits of commissioning an umbrella review from Pubrica.

01Evidence at the Level Decisions Are MadeWhere a field already has several reviews, another review rarely adds clarity. An umbrella review establishes what the existing reviews show collectively and where they disagree.
02Overlap quantifiedCorrected covered area expresses the overlap between reviews as a number, and often shows that apparent agreement comes from the same trials counted several times.
03Appraisal That Informs the ConclusionsAMSTAR 2 and ROBIS applied to every included review, so a critically low review does not carry the same weight as a well conducted one.
04Clear Advice on FeasibilityIf the field is not ready for an umbrella review, we advise you at the scoping stage, at no cost.

Quality Assurance

Our Service Commitments and Limitations

Our service terms are set out in full below so you can review them before you commit.

The Pubrica guarantee

Revision Support Until Agreed Requirements Are Met

We continue revising the work until it meets the requirements agreed within the scope. Rather than offering a refund, which would end the engagement with the work incomplete, we keep working until the agreed requirements are met.

01

Unlimited revisions within the agreed scope

There is no limit on the number or timing of revision rounds within the agreed scope. If the work does not meet the agreed requirements, we revise it. Work outside the agreed scope is quoted separately, and we confirm which applies before any work starts.

02

Corrections at Our Cost

If an error in our analysis or writing needs correcting, we correct it free of charge.

03

Delivered on the date agreed

We quote a delivery date we can meet and work to it. If a milestone is at risk, we inform you in advance.

04

Mutual NDA on request

We sign a mutual non-disclosure agreement before you share any material, at no cost, and we can sign your organisation’s NDA instead of ours.

05

You Retain Final Decisions

We give clear methodological advice and tell you when we disagree with a proposed approach. You make the final decision on everything published in your name.

9.4/10

Average client rating

From 3,000 responses to Pubrica’s post-delivery survey, sent to every client at handover between January 2024 and June 2026. This figure comes from our own records rather than from an external rating service.

Limitations of Our Service We cannot guarantee decisions made by others, such as an editor’s decision, a funding panel’s outcome or a regulator’s assessment. Within the agreed scope, we commit to the work itself: completed to the standards named on this page, delivered on the agreed date and corrected at our cost if we made an error.

FAQs

Umbrella Review FAQs

If your question is not answered here, please ask an expert. No quote is required.

A systematic review synthesises primary studies. An umbrella review synthesises systematic reviews. The method is the same in spirit — a protocol, a recorded search, dual screening, appraisal — but the unit of analysis is a review rather than a trial.

This is why overlap matters in an umbrella review: two reviews can share most of their included trials, so counting both as independent evidence overstates the evidence available.

It is the standard measure of how much the included reviews overlap — how many of the primary studies appear in more than one of them. Low overlap means the reviews are largely independent. High overlap means much of the apparent evidence is the same trials counted again.

It helps determine whether an umbrella review is worthwhile. Above roughly 15%, the synthesis must account for the overlap, and we report the figure so that readers do not assume the reviews are independent.

Usually four or more of adequate quality. With two or three, or where most are rated critically low on AMSTAR 2, an umbrella review inherits their weaknesses and adds little value.

We tell you which applies during the free scoping search, before you commit, and advise you if a systematic review of the primary studies is needed instead.

No. That is a systematic review, and it is a different piece of work with a different price. An umbrella review works at the level of the reviews.

Where the appraisal shows that the existing reviews cannot answer your question, we quote for a systematic review instead of an umbrella review.

Related services

Related Research Services

Services that complement an umbrella review, or replace it where existing reviews are insufficient.

Request a Free Umbrella Review Feasibility Assessment

We assess feasibility free of charge within two business days, including whether a systematic review would answer your question better.

Get a free quote

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