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Evidence Synthesis Services

Living Systematic Review Services

Pubrica keeps systematic reviews current after publication. Our information specialists and subject matter experts run living systematic reviews for guideline groups, HTA bodies, public health teams and life-science companies whose question is a priority, whose answer is unsettled and where trials are still reporting. The service covers a baseline systematic review, monthly searching, updates on a schedule agreed in advance, and a version history that can be audited. It is a retained service rather than a single document.

  • Searched monthly, across the bibliographic databases and trial registries named in the strategy, as Cochrane living review guidance sets out
  • Updated on a rule agreed in advance: either when new evidence could change the conclusion, or at a fixed interval where publication volume is high
  • Suitability assessed against three conditions before work starts: the question is a priority, the answer is unsettled, and new evidence is expected
  • Version control with a change log, so readers know which version they used and what has changed since
  • Agreed stopping criteria, reviewed annually so that the review leaves living mode when it is no longer needed
Scope of a Living Review Included and excluded

Monthly searching of named sourcesIncluded

Screening of everything the search returnsIncluded

Updates on the declared ruleIncluded

Version history and change logIncluded

Continuing after stopping criteria are metNot included; we advise stopping

Baseline → monthly search → screened → triggered → new version

Included in every living review
  • Monthly searching, recorded
  • Update rule set before it starts
  • Every version dated and archived
  • Change log a reader can follow
  • Annual test of whether it should continue
Baseline plus retainerQuoted on cadence and search volume
Searched monthlyDatabases and trial registries
Cochrane LSR guidanceUpdate rules and stopping criteria
ISO 9001:2015Quality management certified · cert. H3CR9TCU20251212INDQM10N

Service Scope

Four Living Systematic Review Service Areas, Available Individually

Each component of a living systematic review can be commissioned separately, whether you are starting from a research question or taking over an existing review.

Baseline review designed for updatingThe first version is a full systematic review. Its search strategy, screening records and extraction template are designed from the start to be re-run at each update.
Agreed update scheduleUpdates run monthly, quarterly or when a trigger is met, as agreed in the protocol. The schedule is stated in the published review so that readers can confirm the review is maintained as described.
Repeat searching, screening and synthesisThe search is re-run in full, new records are screened by two reviewers against the original criteria, and the synthesis is revised. Any change in the conclusion is flagged in the new version.
Published version historyEvery version is dated, the changes between versions are recorded, and previous versions remain available so that the review can be audited.

Who we serve

Researchers and Organisations We Support with Living Systematic Reviews

We support organisations that rely on current evidence for guideline, policy, reimbursement, product and research decisions.

Guideline groups in fast-moving fieldsRecommendations that follow the evidence continuously instead of being rewritten from scratch every three years.
Public health and infectious disease teamsEvidence that changes weekly during an outbreak and must be defensible on the day it is used.
HTA bodies and payersA submission-grade review kept current through an appraisal cycle rather than fixed at the date of the search.
Pharmaceutical and biotechnology teamsCompetitive and comparative evidence maintained across a product lifecycle, with the update schedule contracted rather than ad hoc.
Research groups with a standing questionA standing review that serves as the current reference point for a field.
Journals and societies commissioning living evidenceA review built to a publisher’s living-evidence requirements, with the versioning their platform expects.

Deliverables

Four Deliverables Included in Every Living Review

Monthly searching is only part of the service. Each living review also includes rules, agreed in advance, for deciding when new evidence justifies a new version.

Suitability assessment against three conditions A living review is appropriate when the question is a priority for a real decision, the evidence is uncertain, and new studies that could change the conclusion are expected. All three conditions must be met.

From the scoping callMost topics fail at least one condition. Where yours does, we will recommend a systematic review with a planned update in two years instead of a retainer.

Update rule agreed in advance Either event-driven, with an update when evidence arrives that could change the conclusion, or fixed-interval where publication volume is high enough that a trigger-based approach would not keep the review current.

From the protocolThere are no established numerical thresholds for triggering an update, so the rule is agreed with you in advance instead of being decided each month by the screening team.

Dated and archived versions with a change log Each version records its search date, what was added, what changed in the synthesis and whether the conclusion changed, so readers know which version they acted on.

From the change logWithout a version history, a living review changes without notice, which is less useful to a decision-maker than a review that is openly out of date.

Annual review of stopping criteria When the question is settled, is no longer a priority, or new research stops appearing, the review should leave living mode. We assess this every year and report the result to you.

From the annual reviewBecause continuing a retainer is in our commercial interest, this annual test is written into the agreement from the start.

Samples are illustrative and anonymised. Hover over a sample to replay it.

Compliance and Standards

Living Systematic Review Reporting and Methodological Standards

A living review must meet systematic review standards and the requirements of its maintenance protocol.

Cochrane Handbook (and methods group guidance)

The conduct reference for systematic reviews, with the Rapid Reviews Methods Group interim guidance and the living systematic review guidance for the two variants that depart from it deliberately.

PRISMA 2020 (review reporting)

The reporting standard for systematic reviews: the flow of records, the search reproducibility, and the studies excluded at full text with a reason for each.

PRISMA-S (search reporting)

The 2021 search extension to PRISMA 2020. Its sixteen items cover where, how and when you searched and what you found, so that the search can be reproduced.

ISO9001:2015

Quality management (cert. H3CR9TCU20251212INDQM10N)

Our quality management system covers how work is run, recorded and released.

Responsible Use of AI

Responsible Use of AI and Disclosure Across Review Updates

Automation tools are useful when a search is re-run every month. They also need careful disclosure, because the tool is used at every update while the methods section is written once.

What we use it forPrioritising records on each re-run, deduplicating against the previous version, and flagging records that could change a conclusion so that a reviewer assesses them first.
What we do not use it forUnsupervised inclusion or exclusion decisions at any update, decisions about whether a conclusion has changed, and carrying an AI declaration from an early version into later versions without checking that it is still accurate.
What goes in your declarationThe tool, the stage it was used at, and the human oversight applied — because journals, funders and the ICMJE January 2026 update all now expect it, and an undeclared tool found later is treated as a research integrity matter rather than a style preference.

Why We Do Not Publish AI Accuracy Figures

Accuracy figures for AI tools are usually reported by the companies that sell them.

Pubrica does not quote a self-generated accuracy figure, because it would carry the same conflict of interest. Instead, we tell you which tool was used on your project, at which stage, and what a reviewer changed afterwards.

Methodology

How a Living Systematic Review Project Works

Each project begins with a standard systematic review. The later stages cover maintenance after the first version is published.

Step one

Suitability assessment and baseline review

We test the three conditions and then conduct a full baseline systematic review that is registered, dual screened and reported to PRISMA 2020.

Step two

Maintenance protocol

The search cadence, update trigger, versioning convention and stopping criteria are agreed in writing before the first update is due.

Step three

Monthly search cycle

Databases and registries are searched monthly, new records are screened, and the result is recorded whether or not it triggers an update.

Step four

New versions and annual review

A new version with a change log is published when the update rule is met, and each year we assess whether the review should remain living.

Our experts

Your Living Systematic Review Team

Your project is handled by a named team rather than an allocated pool. The same team stays with the project from scoping to delivery, and your project coordinator introduces each member before work begins.

Dr. AntonyInformation specialist

Develops and documents the literature search. Writes the search strategy line by line for each platform and delivers it dated and reproducible.

Responsible forSearch and retrieval
Standards appliedPRISMA-S, PRESS
Second-checked byA second information specialist
Subject expertA subject matter expert matched to your topic

Determines what the evidence can support. Matched to your topic, and tells you plainly when the evidence does not support the conclusion you expected.

Responsible forQuestion, scope, interpretation
Standards appliedICMJE, COPE, PRISMA
FieldMatched to your topic
Dr. DivyaPhD in Life Science · second reviewer

Screens and extracts independently of the first reviewer and reconciles the results, because most errors in this work are transcription errors. Disagreements are logged and adjudicated.

Responsible forIndependent second read
Standards appliedRoB 2, ROBINS-I, QUADAS-3, JBI
Adjudicated byA third reviewer
Mr. JohnM.Sc. in Statistics · statistician

Responsible for the statistical analysis. Confirms before analysis whether the data can answer the question, and delivers the code so that the analysis can be reproduced independently.

Responsible forAnalysis and certainty
Standards appliedGRADE, SWiM, ICH E9
ToolsR, Stata, SAS, RevMan

Pricing

Living Systematic Review Packages and Pricing

Living systematic reviews are priced as a subscription. The baseline is priced as a systematic review, and a retainer covers the ongoing searching, screening and updates.

Baseline

Baseline Systematic Review

The first version of the review

Quoted per projectPriced as a systematic review

Delivery By scope

  • ✓Suitability tested against the three conditions
  • ✓Full systematic review conducted
  • ✓Protocol registered
  • ✓Dual screening and risk of bias
  • ✓PRISMA 2020 reporting
  • ✓Maintenance protocol agreed at handover

The baseline is a standard systematic review and is priced as one. It must be completed before maintenance can begin.

Deliverables Request a quote
Monthly

Monthly cadence

Fast-moving fields

Quoted per projectRetained, quoted on search volume

Delivery Monthly search

  • ✓Monthly search of databases and registries
  • ✓All new records screened
  • ✓Update published when the rule fires
  • ✓Change log maintained
  • ✓Quarterly summary of what did not trigger
  • ✓Annual suitability test

Suited to topics where a single trial can change the conclusion. Most COVID-era living reviews used this cadence.

Deliverables Request a quote
Interval

Fixed-interval cadence

Steady fields with high volume

Quoted per projectRetained, quoted on interval

Delivery Every four or six months

  • ✓Monthly search, batched screening
  • ✓Update published on the interval regardless
  • ✓Change log maintained
  • ✓Conclusion movement flagged between versions
  • ✓Annual suitability test

Costs less than monthly publication and suits fields where evidence arrives steadily rather than through single decisive studies.

Deliverables Request a quote

Send us your question and we will assess it against the three conditions at no cost. If it does not meet one of them, we will tell you, because a systematic review with a planned update is often the better option and costs less.

Benefits

Benefits of a Pubrica Living Systematic Review

The main reasons organisations commission a living systematic review.

01Current evidence when it is usedA conventional review starts to date as soon as the search closes. A living review states when it was last re-run, so readers know how current its conclusions are.
02Lower cost than repeating the reviewRe-running a maintained search costs a fraction of commissioning a new review every few years, because the protocol, the screening records and the extraction template already exist and were built to be reused.
03Auditable version historyDated versions, recorded changes and a retained history show what the review said before and why it changed, which guideline groups and assessors need in order to rely on it.
04Scheduled and budgeted updatesThe cadence is agreed and quoted in advance, so updates follow a planned schedule and budget.

Quality Assurance

Our Service Commitments and Limitations

Our terms are set out in full below, before you commit to a project.

The Pubrica guarantee

Revision Support Until Agreed Requirements Are Met

We continue working on the deliverable within the agreed scope until it meets the agreed requirements. We offer continued revision rather than a refund, because a refund ends the engagement without delivering the work.

01

Unlimited revisions within the agreed scope

There is no limit on revision rounds and no time limit. If the work does not meet what we agreed, we revise it. Any widening of scope is quoted separately, and we confirm which applies before work starts.

02

Corrections at our cost

If work needs correcting because of an error in something we ran or wrote, we correct it free of charge.

03

Delivered on the date agreed

We quote a date we can meet. If a milestone is at risk, we tell you early.

04

Mutual NDA on request

Signed in both directions before you send any material, at no cost. We are happy to sign your NDA rather than requiring ours.

05

Final decisions remain with you

We advise, give our view and tell you clearly when we disagree. You decide what is published in your name.

9.4/10

Average client rating

From 3,000 responses to Pubrica’s own post-delivery survey, sent to every client at handover, January 2024 to June 2026. The figure comes from our own records.

Service limitations. We cannot guarantee outcomes decided by others, such as an editor’s decision, a funder’s panel or a regulator’s assessment. Within the agreed scope, we guarantee the work: completed to the standards named on this page, delivered on the agreed date, and corrected at our cost if we made an error.

FAQs

Living Systematic Review FAQs

If your question is not answered here, please ask an expert. No quote is required.

Monthly, across the bibliographic databases and trial registries named in the search strategy. Grey literature and other sources are usually searched less often, and the schedule for each is stated in the protocol.

Monthly searching does not mean monthly publication. In most months the search finds nothing that meets the update trigger, and that result is recorded.

According to the rule agreed at the start: either when evidence arrives that could change the conclusion, or at a fixed interval.

There are no established numerical thresholds for this in the methods literature, which is why the rule is set in advance rather than decided case by case.

When any of the three conditions no longer holds: the question stops being a priority, the answer becomes settled, or new research stops arriving. We assess this annually and report the result to you.

A living review that is no longer needed is an ongoing cost without a reader, and we will recommend ending it.

Usually. We assess whether the original search is reproducible and the protocol adequate, and tell you what must be rebuilt before the review can be maintained.

If the original search cannot be re-run, the baseline review has to be redone.

Yes. Living systematic reviews are published in journals that support versioning, and in the Cochrane Library.

Where your target journal does not support versioned publication, the review can still run as a living evidence service internally, with periodic publications drawn from it.

Related services

Related Research Services

Services that provide the baseline for a living review, faster review types, and evidence reviews for submissions.

Request a Free Suitability Assessment for a Living Review

If your question does not meet one of the three conditions, we will recommend a systematic review with a planned update, which costs less than a retainer.

Get a free quote

Regulations

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