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Patients with metabolic syndrome and heart failure (HF), frequently also have concurrent kidney dysfunction, which has recently been defined as cardiovascular-kidney-metabolic (CKM) syndrome. The plasma metabolomics profiling of patients with metabolic syndrome previously identified a plasma branched chain amino acid (BCAA) signature, and BCAAs are also elevated in the myocardium of patients with HF, presumably due to a disruption in the BCAA’s catabolic breakdown
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