A shadow in the treatment of acute leukemia: lineage switch
Simplified Abstract
Sample Work
Lineage switch is a rare entity in acute leukemia in which AML transforms into ALL, or vice versa, while retaining a common clonal origin. It may result from clonal selection, genetic mutations, or treatment-related factors. Accurate diagnosis is essential to distinguish lineage switch from secondary leukemia. Case reports and physician experiences provide valuable insights into its clinical presentation, diagnostic challenges, treatment strategies, and outcomes. Given its generally poor prognosis, early recognition and appropriate lineage-directed management are essential.
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