The Microbiome in COPD: Emerging Potential for Microbiome-Targeted Interventions

Chronic obstructive pulmonary disease (COPD) is a leading global health concern characterized by persistent airflow limitation and chronic inflammation. Recent research highlights the respiratory microbiome as a key factor influencing COPD development and progression. Microbial imbalance, or dysbiosis, may contribute to airway inflammation, exacerbation, and treatment response. Environmental exposures such as smoking, pollution, and diet further shape the respiratory microbiome. Understanding these interactions offers new potential for microbiome-targeted interventions in COPD management.