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Haematopoiesis, the production of blood cells, has long been attributed to a small number of haematopoietic stem cells. However, the dynamics of native haematopoiesis are unclear. This study presents a novel mouse model within situ genetic labelling, revealing that steady-state blood production is driven by the recruitment of long-lived progenitors, not just stem cells, challenging traditional views of haematopoiesis.
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