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Controlled clinical trials are the highest level of clinical research and are very helpful in giving insight into the effectiveness of different interventions. Whether the intervention is a new drug, dietary supplement, or behavioral intervention, CCTs ensure that the results obtained are reliable and valid. Designing and conducting a controlled clinical trial involves several crucial steps, from defining the research question to data analysis and reporting. It lists the basic principles and guidelines necessary for designing and conducting controlled clinical trials, including illustrative examples and best practice recommendations from a variety of sources.
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