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Academy · Research Writing · Effect size vs significance

Effect Size Versus Statistical Significance: The Limits of the P Value

Statistical significance indicates that a result is unlikely to be due to chance alone; effect size indicates the magnitude of the result. A study may achieve statistical significance without the effect being clinically meaningful. This article explains the distinction and its implications for reporting.

Pubrica AcademyWritten by a biostatistician Reviewed byan epidemiologist Published10 October 2026 Last checked10 October 2026 Reading time6 minutes Sources1 peer-reviewed

Statistical significance (typically p < 0.05) indicates a result is unlikely under the null hypothesis. Effect size is a standardised measure of the magnitude of a difference or relationship, independent of sample size. A large enough sample can make a trivial effect statistically significant, which is why effect size, not significance alone, should drive judgements of practical importance.

Learning objectives

  • Why sample size inflates statistical significance without inflating the underlying effect.
  • The common standardised effect-size measures and what they are used for.
  • Why reporting guidelines increasingly require effect sizes, not p-values alone.

Common misconceptions

  • “A statistically significant result is automatically an important one.” Sullivan and Feinn demonstrate that with a sufficiently large sample, even a very small, practically unimportant difference becomes statistically significant — significance reflects sample size and effect size jointly, so it cannot be read as a stand-in for practical importance on its own.
  • “Effect size and significance measure the same thing in different units.” They answer different questions: significance (the p-value) addresses whether an observed difference is likely due to chance; effect size addresses how large that difference is, and the two can move independently of each other as sample size changes.

Statistical significance of trivial effects in large samples

Sullivan and Feinn illustrate the point directly: statistical significance is a function of both the size of an effect and the size of the sample, so as sample size grows, increasingly small and practically trivial differences become statistically significant1. A p-value therefore cannot, by itself, tell a reader whether an effect is large enough to matter in practice — only whether it is larger than chance would be expected to produce, at the given sample size.

The standardised effect-size measures in common use

Standardised effect-size measures express the magnitude of a difference or relationship independent of the original units and the sample size, letting results be compared across studies. Common examples include Cohen's d (the standardised mean difference between two groups), the correlation coefficient r, and odds ratios or risk ratios for binary outcomes1. Conventional benchmarks exist (for example, Cohen’s approximate guide of small/medium/large for d), but these are general heuristics, not substitutes for judging an effect’s size against what matters clinically in the specific field.

Effect sizes in current reporting guidance

Sullivan and Feinn argue, consistent with guidance from bodies such as the American Psychological Association, that reporting an effect size alongside the p-value is now expected practice, precisely because it lets a reader judge practical or clinical significance directly rather than inferring it — incorrectly — from statistical significance alone1. A results section that reports only p-values, without accompanying effect sizes and confidence intervals, leaves the reader unable to judge whether a “significant” finding is important in practice.

Key points

Key points

Statistical significance depends on sample size as well as effect size; a p-value alone therefore cannot show whether a result is practically important. Effect sizes reported alongside the p-value enable readers to judge practical importance.

Practical application

Practical application

  1. A standardised effect size should be reported for every significant result. Include Cohen's d, an odds/risk ratio, or another appropriate standardised measure alongside the p-value, not instead of it.
  2. The effect size that would be considered clinically meaningful should be stated before analysis. Pre-specify a minimum clinically important difference where possible, rather than judging importance only after seeing the significance result.
  3. A significant result from a very large sample should be interpreted with caution. The effect size should be examined explicitly, because a significant p-value from a large sample may correspond to a practically trivial difference.

Frequently asked questions

No — the appropriate measure depends on the outcome type (continuous, binary, correlational) and the study design; the choice should match standard practice for that design.

Yes, particularly in small or underpowered studies — a meaningful effect size with a wide confidence interval that does not exclude zero may still warrant further, better-powered study rather than being dismissed.

No — these are general heuristics from behavioural research; many fields, especially clinical medicine, should judge effect-size importance against field-specific, clinically meaningful thresholds rather than generic benchmarks.

References

  1. Sullivan GM, Feinn R. Using Effect Size—or Why the P Value Is Not Enough. Journal of Graduate Medical Education. 2012;4(3):279-282. read 10 October 2026. View on PubMed Central

Every source above is a peer-reviewed article, a publisher’s record of one, or a standard issued by the body that owns it. Each carries the date it was last read. Where a standard moves, this article is revised rather than left up with a note.

How to cite this article

Pick your referencing style and copy it. Your university or target journal may vary the punctuation — check its guide if it has one.

Pubrica Academy. (2026, October 10). Effect Size Versus Statistical Significance: The Limits of the P Value. Pubrica. https://pubrica.com/academy/concepts-definitions/effect-size-vs-statistical-significance/

This article is written to be learned from. Cite it if you are referring to what it says; if you are using the evidence behind it, cite the sources listed above instead.

Effect-size reporting check

Use when finalising the results section.

[ ] Standardised effect size reported for every significant result
[ ] Effect-size measure matches the outcome type and study design
[ ] Minimum clinically important difference stated, ideally pre-specified
[ ] Large-sample significant results checked against effect size for practical importance
[ ] Confidence interval reported alongside the effect size

Pubrica AcademyWritten and maintained by Pubrica’s subject matter experts. Articles are revised when the underlying standards change, and each article states the date on which it was last reviewed.

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Pubrica reviews manuscripts to ensure that every significant result is accompanied by an appropriately chosen and correctly reported effect size, so that reviewers can assess practical as well as statistical significance.

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