How to write a Manuscript: Components and Structure of Manuscript writing

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The goal of manuscript writing is to go beyond simply presenting facts and ideas. It is to reach out to the reader to successfully explain your findings and assist readers in comprehending the topics at hand. This blog introduces and shows several techniques for arranging a manuscript so   

The goal of manuscript writing is to go beyond simply presenting facts and ideas. It is to reach out to the reader to successfully explain your findings and assist readers in comprehending the topics at hand. This blog introduces and shows several techniques for arranging a manuscript so that readers remember the most important messages you want to communicate after reading it.  

Although manuscript writing has a strict format, there is still room to weave a captivating story that communicates the science while still being enjoyable. Scientists, authors, and editors discuss the value and significance of creativity and how to create a great study.

Make sure your message is clear

Consider the message you wish to send to your readers. If that isn’t clear, there may be later misinterpretations. When a multidisciplinary group of authors is becoming more common, a clear message is even more crucial. I encourage groups to meet in person and seek consensus on the main message and the data selection, visual presentation, and information needed to convey a powerful message. The main text should contain the most crucial information, and additional data should be placed in the supplementary content to avoid distraction. Countless manuscripts are turned down because the discussion part is so lacking that it’s plain the author doesn’t understand the existing literature.  Writers should place their findings in a larger context to show what makes them valuable or unique.

There is a fine line between hypothesis and evidence-based judgments to be drawn. In the conversation, a writer can conjecture but not excessively. It’s never good when the conversation is just guesswork because it’s not based on the author’s experience. Include a one- or two-sentence statement in the end on the study you want to conduct in the future and what else needs to be investigated.

Components and structure of Manuscript Writing

After the title and abstract, the first part of a research paper is the abstract. It is usually short and communicates the scope of the research paper writing (the rationale and goal of the investigation). It should include the study’s background (the existing body of knowledge), significance, and objectives. It should explicitly explain or describe the research questions/hypotheses being tested.

Manuscript writng


The approach used determines whether or not a study is valid. The Methodology section should be given in such detail and clarity that other researchers can reproduce the work in their own environment. The section on methodology is divided into two parts: “Materials” and “Methods.”

  • Who/what was studied (e.g., humans, animals, corpses, tissue preparations)?
  • Who/what was inspected (e.g., humans, animals, corpses, tissue preparations)?
  • What types of therapies were used (for example, oral, injectable, and gas)?
  • What tools were employed in the investigation (e.g., HPLC, haemoglobin meters)?

The “Methods” section explains how individuals were manipulated to answer the experimental question, how measurements and computations were performed, and how data was stored and analyzed.

Methodology sub-sections for Research paper writing

The ethical criteria established by the country or region should be mentioned and followed in the Methods section. The ICMR’s Ethical Guidelines for Biomedical Research on Human Participants, for example, are a valuable resource for reference while researching human subjects in India. The ICMR’s Guidelines for the use of Animals in Scientific Research/INSA’s Guidelines for Care and Use of Animals in Scientific Research or the Committee for Control and Supervision of Experiments on Animals (CPCSEA Guidelines) for Care and Use of Animals in Scientific Research (CPCSEA Guidelines) for Care and Use of Animals in Scientific Research (INSR).

The Methodology sections of manuscript writing are the final subcomponent deals with data management and statistical analysis. In the publication, it is critical to state how data quality was ensured throughout the investigation, including whether a single or double data entry approach was utilized for data management. As part of the data management technique, the authors should specify whether consistency or random checks were performed. It’s critical to include the name of the statistical programme used for data entry and analysis, along with the required references. The Methodology part should always be written in the past tense and presented logically and ordered.


The easiest section to write is the Results section for manuscript writing. In this section, one must describe the intervention/findings. Observation’s Text, Tables, and Graphs are the most common components of the Results section. So that unnecessary duplication of material supplied in tables and figures is avoided in the text. The text should deliver unique information and highlight the most significant features of the figures and tables. Only the most critical points should be underlined or summarized. It is not necessary to display the same data in tables and figures.


One of the most challenging portions of a manuscript to write is the Discussion section. The commentary adds value to the paper by comparing the authors’ work to that of other scientists. The discussion should be on the interpretation (findings), and the debate should focus on how the study results contribute to the overall picture. Current manuscript writing, explain the findings and compare the study’s conclusions. Discuss the limits and, if possible, the implications for future research after comparing your results to other literature. A summary is usually given at the end of the conversation.


It’s important to recognize people who don’t fit the authorship standards, and the acknowledgement should be brief and limited to particular scientific or technical aid and financial support. Individuals who provide standard departmental services and help produce manuscript writing without actually contributing to scientific content are not needed to be acknowledged.


The manuscript’s writing type and nature determine the overall number of references. It’s always a moral idea to check the “Instructions to the Authors” page for specific instructions. Citations should be numbered in the same order as they appear in the text and placed after the document. The referencing style varies on the magazine, so careful consideration should be given before journal publication.

About Pubrica

Pubrica’s manuscript writing service has worked with several medical and scientific journals. The Pubrica Researcher Team creates a solid review that can be a valuable tool for practitioners, offering a concise synthesis and analysis of the relevant information in a specific field.


  1. Virginia Gewin How to write a first-class paper; nature 16 March 2018.
  2. Sitanshu Sekhar Kar, Rakhee Kar Components and Structure of a Manuscript, Writing and Publishing a Scientific Research Paper pp 9-15.

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