The improvement of intestinal dysbiosis and hepatic metabolic dysfunction in dextran sulfate sodium-induced colitis mice: effects of curcumin

Inflammatory bowel disease (IBD), encompassing Crohn’s disease and ulcerative colitis, is a chronic inflammatory condition with increasing global prevalence and limited long-term therapeutic success. Conventional treatments are often associated with suboptimal response and adverse effects, prompting interest in safer adjunct therapies. Curcumin, a natural polyphenol derived from Curcuma longa, exhibits potent anti-inflammatory, antioxidant, and immunomodulatory properties and has shown beneficial effects in experimental and clinical IBD studies. However, clinical outcomes remain inconsistent and the mechanisms of action are not fully understood. This study examines current evidence on curcumin’s efficacy, safety, and mechanistic role in IBD management.