Clinical Literature Review for an Evidence-based Medicine

Systematically analyze and synthesize clinical research to support evidence-based decision-making and improve patient care outcomes.

Professional Clinical Literature Review for Evidence-Based Medicine: Interpret Scientific Evidence with Rigor, Relevance, and Reliability

At Pubrica, we specialize in providing systematic, high-quality clinical literature reviews to support evidence-based medical decisions, clinical guideline development, clinical trial design, regulatory submissions, and other exploratory research activities.

Our services are tailored to meet the needs of physicians, surgeons, healthcare providers, as well as pharmaceutical and medical device companies, by providing reliable, scientifically validated insights through systematic review writing and high-quality medical writing.

Synthesizing validated clinical evidence from peer-reviewed literature
Contributing to clinical practice guidelines, protocols, and trial designs
Shaping health technology assessments (HTA) and regulatory submissions.

We also support early-stage research by:

Investigating unmet medical needs
Exploring novel therapeutic areas
Reviewing existing literature before initiating preclinical or Phase I clinical trials

Using Pubrica’s multidisciplinary team consisting of clinical researchers, epidemiologists, biostatisticians, and content experts, we can ensure the medical literature review is accurate, methodologically robust, and clinically valid.

Clinical Literature Review Services We Offer

Pubrica provides end-to-end support for a comprehensive literature review to advance clinical research, product development, and regulatory strategy. Our services include:

Systematic Literature Review (SLR)

Robust process that can be replicated
PRISMA-compliant process
Risk of bias assessment
Meta-analysis (if applicable)

Narrative Literature Review

Broad overview of a clinical topic
Expert syntheses of key findings
Good for white papers, background sections, or medical education

Scoping Review

Mapping key ideas and research gaps
Best for early-phase research or new therapy areas

Targeted Literature Review (TLR)

Focused review of subject matter, populations, or outcomes
Supports health economics, value dossiers, and HTA filings

Literature Review for Regulatory Submissions

Compilation of evidence for an IND, NDA, BLA, 510(k), or CE mark
Aligns with FDA/EMA guidelines and regulatory requirements

Clinical Trial Protocol Support

Literature-based background and justification for the trial design
Identify endpoints, comparators, and safety considerations

Health Technology Assessment (HTA) Support

Literature reviews to support reimbursement and payer submissions
Cost-effectiveness, clinical effectiveness, and real-world evidence

Gap Analysis and Competitive Landscape Reviews

Identify unmet medical needs
Analyse current therapies and competitor pipelines

Early Research & Pipeline Support

Literature evidence to guide preclinical and Phase I trial planning
Evaluation of novel therapeutic targets or indications

What We Review

At Pubrica, we provide comprehensive review for EBM covering a broad range of topics to support pharmaceutical companies, medical device manufacturers, healthcare providers, and biomedical innovators. We conduct evidence synthesis across:

Diseases, Conditions &
Populations

Specific medical conditions (e.g., oncology, cardiology, infectious diseases, rare diseases)
Special populations (e.g., paediatric, geriatric, pregnant patients, immunocompromised)
Comorbidities and risk stratification

Drugs, Ingredients & Biological Substances

Active pharmaceutical ingredients (APIs)
Excipients and delivery system materials
Biosimilars and biologics (e.g., monoclonal antibodies, vaccines)
Natural compounds and traditional medicine ingredients (e.g., plant-based actives)
Raw materials in drug development and manufacturing

Medical Devices, Materials & Technologies

Diagnostic equipment components (e.g., MRI, CT, X-ray, ultrasound)
Surgical and implantable materials (e.g., titanium, biodegradable polymers, ceramics)
Dental materials and prosthetics
Biocompatibility, durability, and performance evaluations
Wearable devices and digital health technologies
3D-printed biomedical devices and materials

Clinical Interventions &
Outcomes

Treatment efficacy and safety
Comparative effectiveness
Quality of life and patient-reported outcomes (PROs)
Adherence and treatment burden

Health Economics & Real-World
Data

Cost-effectiveness and value assessments
Budget impact analyses
Real-world evidence (RWE) integration
Post-marketing surveillance and pharmacovigilance data

Emerging Areas & Interdisciplinary Research

Artificial intelligence in healthcare
Personalized and precision medicine
Nanotechnology and bioengineering materials
Telemedicine and virtual care models
Sustainability in medical product design

Our Approach

Pubrica offers systematic, detailed, and methodologically sound clinical literature reviews to facilitate evidence-based decision-making in healthcare. Our services integrate Systematic Review Support to objectively appraise and synthesize the latest clinical evidence, enabling the client to incorporate vetted research findings into clinical, procedural, policy documents, grant proposals, and the development of medical products.

Our expert medical writers and domain specialists:

Use databases, including PubMed, Embase, Cochrane Library, Scopus, and CINAHL to conduct targeted, thorough, and reproducible literature searches
Utilize evidence-based processes like PRISMA, MOOSE, and AMSTAR 2 processes for systematic and scoping reviews
Appraise the quality of evidence using GRADE, Jadad scale, or Newcastle-Ottawa tools so that each study appraised and graded is recorded transparently
Summarize using true qualitative, quantitative, or both quantitative and qualitative methods, including meta-analysis, narrative synthesis, or evidence mapping
Produce clinically-focused summaries and tables to PICOT characteristics and clinical endpoints

Our EBM literature review is compliant with ICMJE, CONSORT, and EQUATOR standards, enhancing the credibility, reproducibility, and academic value of the research.

Who We Serve

At Pubrica, we provide expert-driven research writing support designed for stakeholders in medical research, health care decision-making, and regulating agencies.

Pharmaceutical and Biotech Companies

For drug development documentation, mechanism-of-action reviews, safety/efficacy evaluations, and literature support for regulatory dossiers (e.g., IND, NDA, CTD).

Medical Device and Diagnostic Firms

To support clinical evaluation reports (CER) (CE marking, 510(k), PMA), white papers, and technical documentation for regulatory approvals (e.g., EU MDR, FDA).

Healthcare Providers and Clinical Practitioners

To support diagnostic decisions, treatment planning, CME, and practice guideline development through structured synthesis of recent clinical evidence.

Academic and Research Institutions

For dissertation development, thesis writing, academic literature review, topic mapping, gap analysis, and peer-reviewed journal publications, requiring methodologically sound and publication-ready literature review is required.

Regulatory & Government Agencies

Evidence gathering for public health programs, Data reviews for health policy decisions, and technical documentation for compliance and surveillance.

Hospitals and Medical Research Units

To facilitate clinical audits, protocol development, institutional ethics committee submissions, and internal training material based on updated clinical findings.

Biomedical & Material Science Companies

Literature on biomaterials, polymers, nanomaterials, and coatings, technical and safety reviews for medical-grade raw materials, and device-material interaction and biocompatibility studies.

Contract Research Organizations (CROs)

To aid in clinical trial documentation, literature-based justification of endpoints, and background sections for study protocols or investigator brochures.

Health Technology Assessment (HTA) & Market Access Teams

Cost-effectiveness and value demonstration. Comparative effectiveness and outcomes evidence and support for payer submissions and value dossiers.

How Our Clinical Literature Review Service Works

Our step-by-Step Process

Clinical literature reviews should use a protocol-driven and reproducible six-step process to ensure that they adhere to the highest standards of evidence-based medicine (EBM), regulatory compliance, and scientific integrity.

Define Research Objective

We work with you to formulate a specific, clinically relevant research question using the PICO (Population, Intervention, Comparator, Outcome) or SPIDER methodology

Protocol Development

Prepare review protocols based on PRISMA-P or the JBI guidelines

Comprehensive Literature Search

Conduct a systematic search of databases including PubMed, Embase, Cochrane, Scopus, and Web of Science

Study Screening & Selection

Two-level screening (title/abstract followed by full-text) is performed using PRISMA-compliant flow diagrams

Data Extraction and Quality Appraisal

Standardized templates to extract study characteristics, interventions, outcomes, and results. Quality assessment using validated tools (e.g., GRADE, Jadad Scale, or Newcastle-Ottawa Scale), depending on the study design

Evidence Synthesis and Reporting

Depending on the scope, we perform: Narrative synthesis, meta-analysis, or evidence mapping. Results are presented using forest plots, summary of findings tables, and clinical interpretation

Speed up your clinical literature review writing service with Pubrica

Pubrica provides a medical literature review service which provides a detailed guide to help you to identify the right journal for your paper. Our service provides comprehensive analysis based on scope, range of impact factor, indexing requirements, and more, based on your paper and your preferences.

Our Compliance and Guideline Standards

At Pubrica, all our clinical literature review services are rooted in accepted internationally recognized standards and frameworks to guarantee methodological rigor, transparency, scientific validity, and regulatory readiness. Our processes are guided by best practices in scientific research and industry-specific requirements.

Methodological Guidelines

Compliance Guidelines

PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses)

For transparent and standardized reporting of systematic reviews.

Cochrane Handbook for Systematic Reviews of Interventions

For evidence-based methodology and quality assessment.

JBI (Joanna Briggs Institute) Guidelines

For scoping reviews, evidence summaries, and qualitative syntheses.

Regulatory Compliance and Industry Standards

ICH Guidelines including E6, E3, E9

ICH Guidelines (E6, E3, E9, etc.)

For clinical trial design, reporting, and statistical methods.

FDA and EMA Standards

For regulatory submissions including IND, NDA, BLA, and 510(k).

CE Marking and EU MDR

CE Marking & MDR (EU Medical Device Regulation)

For medical device literature reviews and clinical evaluation reports (CER).

CONSORT and STROBE Guidelines

CONSORT & STROBE Guidelines

For assessing clinical trials and observational studies.

Good Publication Practice GPP3

Good Publication Practice (GPP3)

For ethical and transparent reporting of medical writing.

Clinical Literature Review Sample Work

Discover More

Download the full Report Now

Explore our clinical literature review samples, systematically developed to meet journal submission standards, evidence-based methodology, and stringent timelines for regulatory or academic use.

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Clinical Literature Review for Evidence-Based Medicine – Packages

Pubrica works with flexible, tiered plans to collect and report on a wide range of evidence synthesis needs across academic, clinical, and industry purposes. Each package meets international methodological standards (PRISMA, JBI, Cochrane) while reflecting the project’s scope, depth, and urgency.

Starts From $ 45 / Hour

Testimonials

Our clinical literature review services have helped global researchers, clinicians, and industry experts publish high-quality, evidence-based reviews in top-tier journals. Here’s what our clients say:

"Pubrica’s team delivered a systematic review on anticoagulant therapy in atrial fibrillation that surpassed our expectations. The review followed PRISMA and GRADE methodology with well-structured forest plots and bias assessments. The work was published in the European Journal of Internal Medicine.”

Dr. Elena Hoffman,

Clinical Research Director, Germany Flag

"We needed a rapid literature review for oncology treatment patterns for internal submission, and Pubrica responded with accuracy and speed. The document aligned with ICMJE standards and supported our publication in the Journal of Cancer Research and Therapeutics.”

Dr. Anil Menon,

Medical Affairs Lead, India

"Pubrica conducted a meta-analysis on paediatric analgesic efficacy that was both statistically robust and clinically relevant. Their adherence to PRISMA and AMSTAR 2 standards facilitated acceptance in the British Journal of Clinical Pharmacology.”

Prof. Samuel Walker,

Department of Clinical Pharmacology, UK Flag

Frequently Asked Questions – Clinical Literature Review Service

1. What is a Clinical Literature Review in the context of Evidence-Based Medicine (EBM)?

A Clinical Literature Review is a structured, critical synthesis of published research aimed at answering specific clinical or scientific questions. Within the Evidence-Based Medicine (EBM) framework, it supports informed healthcare decisions by summarizing the best available peer-reviewed evidence, including clinical trials, guidelines, and real-world data.

2. How is your service different from a standard literature review?

Pubrica’s clinical literature review service follows globally accepted guidelines such as PRISMA, Cochrane, and JBI. We employ:

Structured search strategies
Critical appraisal tools like GRADE or CASP
Clear evidence synthesis aligned with EBM and regulatory expectations

Our reviews are publication-ready, compliant with regulatory standards, and tailored for clinical decision-making or submission dossiers.

3. What types of literature reviews do you offer?

We offer a wide range of evidence synthesis services, including:

Systematic Review
Narrative Review
Scoping Review
Meta-Analysis
Rapid Review
Integrative Review

Each is customized based on your research question, project goals, and target journal or regulatory body.

4. What clinical areas do you specialize in?

Our literature review team has expertise across diverse therapeutic areas, including:

Oncology, Cardiology, Neurology, Endocrinology
Infectious Diseases, Rare Diseases, Public Health
We assign subject-matter experts to ensure domain-specific relevance and accuracy.

5. Do you help with protocol development and registration?

Yes. We assist with:

Protocol writing (using PRISMA-P or JBI guidelines)
PROSPERO registration or other repositories

This ensures transparency, reproducibility, and alignment with publication or regulatory requirements.

6. How do you ensure the quality and validity of included studies?

Our process includes:

Dual independent screening
Use of critical appraisal checklists like GRADE, AMSTAR 2, and CASP
Risk of bias assessment

This ensures that only high-quality, clinically relevant evidence is included in the final review.

7. Which databases do you search?

We conduct comprehensive literature searches across major scientific databases, including:

PubMed/MEDLINE
Embase
Cochrane Library
Scopus
Web of Science

We also search grey literature, clinical trial registries, and regulatory documents as needed.

Insights

Organize journal matching by different decision-making filters: