Mean and Mean difference are the two key statistical measures used in the statistical analysis. Both are essential for meta-analysis as well. Mean and Mean difference are used for the interpretation of a large set of values into a single number which explains the heterogeneity and variation among the individual values. However, one of a common challenge in meta-analysis is the unavailability of this data (mean and standard deviation).
Q & A Forum
Meta Analysis
Q: What are the shortcomings of funnel plots in meta-analysis?
- Inability to confirm bias – In some cases funnel plots states bias but do not confirm it; further statistical interpretations are required to confirm it.
- Subjectivity – Visual explanation of asymmetry can be inconsistent and subjective.
- Misleading asymmetry – effect estimates like odds ratios, risk ratios are naturally associated with their standard precision, leading to extreme asymmetry.
This statement highlight the need for alertness when interpreting funnel plots in meta-analysis.
Refernce:
Cochrane Handbook for Systematic Reviews of Interventions. (2011). 10.4.1 Funnel plots. The Cochrane Collaboration. Retrieved from
https://handbook-5-1.cochrane.org/chapter_10/10_4_1_funnel_plots.htm