Mean and Mean difference are the two key statistical measures used in the statistical analysis. Both are essential for meta-analysis as well. Mean and Mean difference are used for the interpretation of a large set of values into a single number which explains the heterogeneity and variation among the individual values. However, one of a common challenge in meta-analysis is the unavailability of this data (mean and standard deviation).

Q & A Forum

Meta Analysis

Q: How is pooled SD calculated when combining two subgroups into one?

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  • If homogeneous variance is assumed, the Cohen method can be used to pool SD (Formula 15).
cohen method
  • If means of the subgroups are available, the method outlined in the Cochrane Handbook should be used, as it accounts for mean differences (Formula 16).
cohen handbook

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